Hypersensitivity to bupropion or to any of the other components of Wellbutrin XL.
Patients with a seizure disorder; undergoing abrupt discontinuation of alcohol or sedatives; currently being treated with any other preparation containing bupropion, as the incidence of seizures is dose-dependent; with a current or previous diagnosis of bulimia or anorexia nervosa, as a higher incidence of seizures was seen in this patient population when bupropion was administered.
Concomitant use of Wellbutrin XL and monoamine oxidase inhibitors (MAOIs) is contraindicated. At least 14 days should elapse between discontinuation of irreversible MAOIs and initiation of treatment with Wellbutrin XL.